MedlinePlus related topics: Arthritis Osteoarthritis. Drug Information available for: Glucosamine hydrochloride Glucosamine Chondroitin Chondroitin sulfates Glucosamine sulfate. FDA Resources. Arms and Interventions. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.
More Information. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. Arthritis Rheum. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Drug: glucosamine Drug: chondroitin sulfate Drug: glucosamine and chondroitin sulfate combined Drug: celecoxib. Phase 3. Study Type :. For general information, Learn About Clinical Studies. Try the modernized ClinicalTrials. Learn more about the modernization effort. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.
Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : December 29, See Contacts and Locations. Study Description.
Previous studies of the exosuit technology have culminated in strong evidence for the gait-restorative effects of soft robotic exosuits for patients post-stroke by means of substitution for lost function. The present study builds on this work by suggesting that an exosuit's immediate gait-restorative effects can be leveraged during high intensity gait training to produce long-lasting gait restoration.
Current gait training efforts are focused on either quality or intensity. They focus on gait quality often by reducing the training intensity to allow patients to achieve a more normal gait. In contrast, efforts focused on training intensity push participants without focusing on the quality of their movements. These intervention paradigms generally fail to substantially impact community mobility.
In this study, the investigators posit that exosuits can uniquely enable an integration of these paradigms ie, high intensity gait training that promotes quality of movements. To evaluate the effects of REAL gait training, the investigators will use clinical measures of motor and gait function, locomotor mechanics and energetics, and physiologic measures that may infer on motor learning.
The spectrum of behavioral and physiologic data that we will collect will enable us to understand more comprehensively the gait-restorative effects of REAL. Show detailed description. Hide detailed description. Detailed Description:. Arms and Interventions. A soft exosuit is a textile-based wearable robot that is worn on the paretic ankle. Control training refers to similarly structured gait training as with REAL, with the only exception of using soft robotic exosuits.
Control intervention will implement gait training without exosuits. Outcome Measures. This is test of long-distance walking function. This is a test of short-distance walking function. Forward propulsion refers to anterior component of the ground reaction forces that correspond to push-off subtask of the gait cycle. Muscle synergies refers to the coordinated co-activation of muscles during walking.
The dynamic motor control index is a continuous summary metric of muscle co-activations during walking. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Soft exosuits increase walking speed and distance after stroke. Am J Phys Med Rehabil. Save this study. Warning You have reached the maximum number of saved studies Sonification Techniques for Gait Training SonicWalk The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : May 6, See Contacts and Locations. Study Description. Music therapy is widely used in relational and rehabilitation settings. In addition to Neurologic Music Therapy and other music-based techniques, "sonification" approaches were recently introduced in the field of rehabilitation.
The "sonification" can be defined as a properly selected set of sonorous-music stimuli are associated with patient movements mapping. In fact, the auditory-motor feedback can replace damaged proprioceptive circuits with a consequent improvement of the rehabilitation process.
This study proposes the use of musical auditory cues which includes the melodic-harmonic component of the music. The investigators propose to apply and assess the effectiveness of this kind of sonification on gait training and other secondary outcomes in stroke, Parkinson's disease and multiple sclerosis population. Also, the investigators will assess the impact of "sonification" on the level of fatigue perceived during the rehabilitation process and on the quality of life. The study is a multicenter randomized controlled trial and will involve patients that will undergo standard motor rehabilitation or the same rehabilitation but with the sonification support.
The interventions will be evaluated at the baseline, after 10 sessions, after 20 sessions and at follow-up one month after the end of the treatment. The assessment will include functional, motor, fatigue and quality of life evaluations. The collected data will be statistically processed. Show detailed description. Hide detailed description. Detailed Description:. Background: Music therapy is widely used in relational settings.
Aims: To assess the effectiveness of the sonification in the gait rehabilitation in stroke, PD and MS patients. The evaluation of the questionnaires and the statistical analysis will be carried out blindly Assessment: The interventions will be evaluated at the baseline T0 , after 10 sessions T1 , after 20 sessions T2, end of the treatment and at follow-up T3, one month after the end of the treatment. Binary and categorical variables will be presented as a percentage or absolute number.
MedlinePlus related topics: Rehabilitation. FDA Resources. Arms and Interventions. The sonification system is composed by 2 inertial sensors, a computer and a pair of bluetooth headphones connected with the computer.
The same rehabilitation exercises are performed without musical support. The training will be carried out without any musical support. Exercises I Phase Load shift in anteroposterior standing in tandem position, left foot forward 3 minutes exercise with a short break in the middle Load shift in anteroposterior standing in tandem position, right foot forward 3 minutes exercise with a short break in the middle Left foot swing 3 minutes exercise with a short break in the middle Right foot swing 3 minutes exercise with a short break in the middle March in place 3 minutes exercise with a short break in the middle Exercises II phase 15 minutes : the patient will perform 14 minutes of walking with a 1 minute of break in the middle 7 minutes of walking, 1 minute rest, 7 minutes of walking.
In the second part of walking the patient will be asked to slightly increase the pace of the step up to the maximum possible speed. Outcome Measures. Dynamic balance and gait and risk of falls will be evaluated using the Dynamic Gait Index by comparing the variations of the test scores in the experimental and control group. The overall effect of the intervention will be evaluated using the Global Perceived Effect by comparing the variations of the test scores in the experimental and control group.
The fatigue perceived will be evaluated using a Visual Analogue Scale by comparing the variations of the test scores in the experimental and control group. Eligibility Criteria. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. Neural reorganization underlies improvement in stroke-induced motor dysfunction by music-supported therapy.
Ann N Y Acad Sci. Front Neurol. BMC Neurosci. Shared networks for auditory and motor processing in professional pianists: evidence from fMRI conjunction. Epub Dec Baram Y, Miller A. Auditory feedback control for improvement of gait in patients with Multiple Sclerosis.
J Neurol Sci. Epub Feb A network for audio-motor coordination in skilled pianists and non-musicians. Brain Res. Epub Jun 4. Gait improvement via rhythmic stimulation in Parkinson's disease is linked to rhythmic skills.
Sci Rep. Front Neurosci. Symmetry matched auditory cues improve gait steadiness in most people with Parkinson's disease but not in healthy older people. J Parkinsons Dis. Intensive gait training with rhythmic auditory stimulation in individuals with chronic hemiparetic stroke: a pilot randomized controlled study. Relationship between output from MIDI-keyboard playing and hand function assessments on affected hand after stroke.
Epub Mar
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